Carefill 40 mg

• Supports erections during sexual stimulation

• Improves blood flow to the penis

• Helps maintain an erection during intimacy

• May provide an extended response window

• Allows greater flexibility in timing

• Can be taken with or without food

• Comes in a convenient oral tablet form

Carefill 40 mg does not permanently cure erectile dysfunction. Its benefit is present while tadalafil remains active in the body.

Sexual stimulation causes the body to release nitric oxide in the penis. This increases a natural chemical called cyclic guanosine monophosphate, or cGMP, which relaxes smooth muscles and widens the blood vessels supplying the penile tissues.

The PDE5 enzyme normally breaks down cGMP. Tadalafil blocks this enzyme, allowing cGMP to remain active for longer. This supports increased blood flow and makes it easier to achieve and maintain an erection during sexual stimulation.

Tadalafil may remain active for up to 36 hours in some people. This is a response window, not the length of an erection. Sexual stimulation is required each time an erection is wanted.

For erectile dysfunction, tadalafil is usually started at 10 mg taken before anticipated sexual activity. A healthcare professional may reduce the dose to 5 mg or increase it to a maximum of 20 mg based on response and tolerability.

Carefill 40 mg contains a higher amount than the usual maximum single tadalafil dose for ED. It should therefore be taken only when a qualified healthcare professional has reviewed the strength and provided specific instructions.

People with kidney or liver problems and those using certain interacting medicines generally require much lower tadalafil doses. Because Carefill is used when required, there is no missed dose to replace.

Common Side Effects: Headache, indigestion, facial flushing, a stuffy nose, back pain, muscle aches and discomfort in the arms or legs may occur. These effects are often temporary, but medical advice is appropriate if they are severe, continue for a long time or interfere with normal activities.

Serious Side Effects: Seek urgent medical help for chest pain, fainting, severe dizziness, sudden vision loss, sudden hearing loss, facial or throat swelling, breathing difficulty or an erection that is painful or lasts longer than four hours. Do not take another dose until the reaction has been medically assessed.

Carefill 40 mg should not be taken without medical approval by:

• People allergic to tadalafil

• People using nitrate medicines

• People taking riociguat

• Men advised to avoid sexual activity

• People with serious heart disease

• People with very low blood pressure

• People with severe liver disease

• People with serious kidney impairment

• Children and adolescents

• People using another PDE5 inhibitor

Additional medical assessment is needed after a recent heart attack or stroke or when there is uncontrolled blood pressure, an irregular heartbeat or a previous serious eye condition.

Tell your healthcare provider about all medicines, supplements and recreational substances you use.

Important interactions include:

• Nitrate medicines

• Riociguat

• Alpha-blockers

• Blood pressure medicines

• Other PDE5 inhibitors

• Other ED treatments

• Ketoconazole or itraconazole

• Ritonavir and similar HIV medicines

• Certain macrolide antibiotics

• Excessive alcohol

Nitrates and riociguat can interact with tadalafil and cause a dangerous fall in blood pressure. Strong CYP3A4 inhibitors can substantially increase tadalafil exposure, making the 40 mg strength unsuitable.

Do not combine Carefill 40 mg with sildenafil, vardenafil, avanafil, another tadalafil product or any other erectile dysfunction treatment unless specifically instructed by a healthcare professional.

• Keep the tablets in their original packaging.

• Store them in a cool and dry place.

• Protect them from heat and direct sunlight.

• Keep them away from moisture.

• Store them out of reach of children and pets.

• Do not use damaged or discoloured tablets.

• Do not take the medicine after its expiry date.

• Follow any additional instructions printed on the pack.