Accufine 20 mg

• Helps Treat Severe Acne  - Isotretinoin can be highly effective for severe acne that has not responded sufficiently to other treatments.

• Reduces Excess Oil Production - By decreasing sebaceous gland activity, isotretinoin can substantially reduce sebum production and skin oiliness.

• Helps Reduce New Acne Lesions - Lower oil production and changes in follicular activity may help reduce the formation of new acne lesions.

• May Reduce the Risk of Acne Scarring - Controlling severe inflammatory acne can help reduce the likelihood of additional acne-related scarring, although existing scars may require separate treatment.

• Long-Term Improvement - A properly supervised isotretinoin course may provide prolonged improvement after treatment is completed. The response varies from person to person, and some patients may experience acne recurrence.

Isotretinoin acts on several mechanisms involved in acne development.

It reduces the size and activity of sebaceous glands, which decreases the amount of sebum produced by the skin. Lower oil production can help reduce clogged pores and create a less favorable environment for acne formation.

Isotretinoin also affects abnormal follicular keratinization and inflammatory processes associated with acne.

As treatment progresses, patients may notice less oily skin and fewer acne lesions. Improvement is not always immediate and may take several weeks or longer.

There is no single isotretinoin dose that is appropriate for everyone. The prescribed amount may depend on:

• Body weight

• Severity of acne

• Treatment response

• Side effects

• Previous acne treatments

• Other medical conditions

• Other medicines being used

A 20 mg capsule is a strength, not a universal daily dose. Your dermatologist should determine how much isotretinoin you need and how long treatment should continue.

Do not increase the dose because acne is not improving quickly.

Common Side Effects
Possible side effects include dry lips, skin, and eyes; nasal irritation or nosebleeds; sensitivity, headache, muscle/joint discomfort; and temporary liver enzyme or blood lipid changes

Serious Side Effects
Major serious side effects cause severe/persistent headache, vision changes, abdominal pain, jaundice, mood changes, allergic reaction, breathing difficulty, muscle weakness, or signs of increased intracranial pressure Isotretinoin has also been associated with serious psychiatric and neurological adverse events, so significant changes in mood or behavior should be discussed with a healthcare professional.

Accufine may not be appropriate for:

• People who are pregnant

• People planning pregnancy

• People who may become pregnant without following required pregnancy-prevention measures

• Individuals allergic to isotretinoin

• People taking certain interacting medicines

• Patients with certain liver or lipid disorders unless specifically evaluated by a healthcare professional

Isotretinoin should only be used under qualified medical supervision.

Tell your doctor or pharmacist about all medicines and supplements you take.

Important interactions may include:

• Tetracycline antibiotics

• Vitamin A supplements

• Certain acne treatments

• Medicines that may affect the liver

• Other medicines prescribed for skin conditions

Taking isotretinoin with vitamin A supplements may increase the risk of vitamin A toxicity.

Do not start another acne medicine, supplement, or prescription treatment without discussing it with your healthcare professional.

Store Accufine according to the product label.

• Keep capsules in their original packaging.

• Protect them from excessive heat and moisture.

• Keep away from direct sunlight.

• Keep out of reach of children.

• Do not use after the expiry date.